Recombinant Human TNF receptor-associated factor 6 (TRAF6)
Description
Purity > 90% as determined by SDS-PAGE. MW: 75.6kDa. Full Length: 1-522aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Ses to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that ses to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
E3 ubiquitin-protein ligase TRAF6Interleukin-1 signal transducerRING finger protein 85