Purified by immunoaffinity chromatography to ≥ 95% purity as determined by SDS-PAGE, reduced. Gene cloned from Macrophage-cell-tropic HIV-1 YU2 strain and the full length (membrane anchor truncation) recombinant envelope gp160 glycoprotein produced in the Baculovirus Expression System. Specificity: This protein binds to murine monoclonal antibodies of defined epitope specificity and HIV-1 converted human serum polyclonal antibodies in ELISA and Western ELISA. Biological Activity: This protein binds to human T-cell receptor CD4 in ELISA and Western ELISA as determined by CD4/gp160/Anti gp160 mAb-peroxidase capture ELISA. Cell activation Assays pending. Applications: Suitable for use in human diagnostics, CD4 binding, drug screening, human T-cell CD4 receptor binding and co-receptor binding studies.