A potent Nampt inhibitor (IC50 = 5 nM); has antiproliferative activity in U251 glioblastoma, HT-1080 fibrosarcoma, PC3 prostate, MiaPaCa2 pancreatic, and HCT116 colon cancer cell lines (IC50s = 1.8, 2.1, 2.7, 7.4, and 2.0 nM, respectively); led to rapid tumor regression in a U251 mouse xenograft model at a dose of 25 mg/kg once per day,