Purity ~95% (SDS-PAGE). Part of the TGF-beta family, inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic, pituitary and gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development and bone growth depending on their subunit composition. Activin A is a disulfide linked homodimer (two beta-A chains) that binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin. Recombinant Human Activin A is a homodimeric, non-glycosylated protein that has a molecular weight of 26kD. Source: Recombinant protein corresponding to human Activin A expressed in E. coli. Molecular Weight: ~13kD Biological Activity: The ED50 as determined by the ability to induce cytotoxicity of MPC-11 c
Size
10ug
Concentration
n/a
Applications
n/a
Other Names
Activin A, Recombinant, Human (Activin Beta-A Chain, Inhibin Beta-A Chain, Erythroid Differentiation Protein, INHBA, FSH Releasing Protein)