Activin A, Recombinant, Human, Animal Free (Activin-A)
Description
Purity ~97% (SDS-PAGE gel, HPLC). Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin.Human/Murine/Rat Activin A is a 26.0kD disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues. Source: Recombinant protein corresponding to human Activin-A expressed in E. coli. Biological Activity: Determined by its ability to inhibit the proliferation of mouse MCP-11 cells. The expected ED50 is 5x10e5units/mg. AA Sequence: GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANL