11-deoxy-16,16-dimethyl PGE2 is a stable synthetic analog of PGE2. It is an agonist for both EP2 and EP3 receptors.{3620} It is an effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively.{1147} It is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.{2218}