Immunocytochemistry: 1 μg/mL, Immunofluorescence: 1 μg/mL, Western Blot: 1-3 μg/mL
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Description
Acetyl-p53 (Lys382) Antibody (10 H13L14), ABfinity? Rabbit Monoclonal. The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 i