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| Antigenic Specificity | Filaggrin (FLG) |
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| Clone | FLG01 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein G purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Filaggrins are an important class of the intermediate filament-associated proteins which interect with keratin intermediate filaments (Ifs) of terminally differentiating mammalian epidermis. Filaggrins exhibit wide species variations. Filaggrin is expressed only in well-differentiated keratinized epithelial cells. The synthesis of filaggrin varies in types of ichthyosis, and with viral, premalignant and malignant conditions. Filaggrin also appears to be a target molecule for rheumatoid arthritis-specific auto-antibodies in humans. Keratohyalin granules in the granular layer of interfollicular epidermis are predominantly composed of the 400-kD protein profilaggrin. Following a short, unique N-terminal domain, most of the profilaggrin molecule consists of 10 to 12 repeats of the 324-residue filaggrin sequence. Upon terminal differentiation of granular cells, profilaggrin is proteolytically cleaved into filaggrin peptides of approximately 37 kD and the N-terminal domain containing an S100-like calcium-binding domain.Synonyms: FLG |
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| Immunogen | Recombinant Filaggrin protein. Remarks: Mol. Wt. of Antigen: 38 kDa (Flaggrin) and 400 kDa (Profilaggrin). |
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| Other Names | FLG|AW208770|Eask|Fgfr-1|Flt-2|Hspy|ATOD2|Pflg|AW107830|ft |
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| Gene, Accession # | Gene ID: 2312 |
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| Catalog # | ABIN180351 |
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| Price | |
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| Order / More Info | Filaggrin (FLG) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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