Purity ≥ 80%. Control peptide for I2500: IkB alpha Pab Rb xHu Source: Synthetic peptide EFT EDE LPY DDC VGF GQR LTL (linear) NFkB exists in the cytoplasm as a complex with a 38kD inhibitor protein, IkB (MAD-3). Activation of NFkB by different stimuli, including TNFa and PMA, requires the dissociation of the inhibitor protein. Dissociation is regulated by the phosphorylation of IkB on serine residues 32 and 36 which targets IkB for ubiquinitation and proteasome mediated degradation. The NFkB complex then translocates to the nucleus and activates transcription of responsive genes. Applications: Suitable for use in Antibody Blocking.