Immunocytochemistry: 10 μg/mL, Immunofluorescence: 10 μg/mL, Western Blot: 1:100-1:500
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Description
LAMP1 Monoclonal Antibody (LY1C6). Lysosome associated membrane proteins (LAMP1), also known as Igp 120 or IgpA, is a type 1 intergral membrane protein that is transported from trans-Golgi network to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboyxl-terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly invovled in the adhe
Immunogen
n/a
Other Names
CD107a, LAMPA, LGP120, CD107 antigen-like family member A, LAMP-1, lysosome-associated membrane glycoprotein 1, lysosome-associated membrane protein 1