A prodrug of the NSAID amfenac; metabolized to amfenac following topical exposure to ex vivo rabbit cornea; inhibits PG synthase 1 (IC50 = 64.3 μM); inhibits PG synthesis ex vivo in isolated rabbit iris/ciliary body by 59.9-100% at a topical ocular dose of 50 μL of a 0.1% solution; reduces protein and PGE2 accumulation in a rabbit model of acute ocular inflammation when used topically at a concentration of 0.1% prior to paracentesis