Recombinant Human Androgen receptor LBD/Hsp90 complex, GST-tagged
Description
Recombinant Human GST-tagged Androgen receptor ligand-binding domain (AR-LBD) consists of a 218 a.a. GST tag, a 30 a.a. flexible linker and a 285 a.a. AR-LBD, amino acids 449-734. It was produced in complex with human Hsp90 to facilitate native protein conformation and advanced performance in ligand binding and coactivator peptide recruitment assays. Hsp90 is important for both the chaperone-mediated folding of the AR into a high-affinity ligand-binding conformation and the functional activity of the AR. GST tagged AR-LBD, human Hsp90 and human Hsc70 are major components of the complex. Purity >80%