Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated) (CCL18) (AA 21-89) protein (His tag)
Description
Recombinant Human C-C Motif Chemokine 18/CCL18 is produced with our E. coli expression system. The target protein is expressed with sequence (Ala21-Ala89) of Human CCL18 fused with a 6His tag at the N-terminus. C-C Motif Chemokine 18 (CCL18) is secreted protein that belongs to the intercrine β (chemokine CC) family. CCL18 is expressed at high levels in the lung, lymph nodes, placenta, bone marrow, and dendritic cells. CCL18 is a chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. CCL18 may be involved in B-cell migration into B-cell follicles in lymph nodes. CCL18 attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.