Immunohistochemistry (Paraffin): 1:100-1:1000, Western Blot: 1:5000
Reviews / Ratings
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Description
ASXL1 Polyclonal Antibody. ASXL1 is a Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A mo
Immunogen
n/a
Other Names
KIAA0978, MGC117280, MGC71111, ASXL1, putative Polycomb group protein ASXL1, additional sex combs-like protein 1, additional sex combs like 1 (Drosophila)