A potent 5-HT2 receptor antagonist (IC50 = 6.3 nM; Ki = 2.1 nM); has activity at H1, α1-ARs, and DA receptors; Kis = 10, 10, and 220 nM, respectively); induces dose-dependent inhibition of contractile responses to 5-HT in arteries and veins; significantly decreases BP, BPV, and hypertensive organ damage in spontaneously hypertensive rats,
Size
500 mg
Concentration
n/a
Applications
n/a
Other Names
74050-98-9 84001-70-7 R49945 perketan serepress sufrexal 5HT a1 AR DA KJK-945 KJK945 ket R-49945 5HT2 5HT1 H1