Recombinant Human Galectin-3 (carrier-free) (E.coli expressed)
Description
Galectin-3 is a member of the lectin family which includes 15 mammalian lectin members.? Like all galectins, Galectin-3 contains a carbohydrate recognition binding domain of about 130 amino acids that enables the specific binding of β-galactosides.? This protein has been shown to be involved in the cell adhesion, cell activation and chemoattraction, cell growth and differentiation, cell cycle, and apoptosis. Galectin-3 induces pro-inflammatory cytokines and inhibits Th2 type cytokine production. It chemoattracts monocytes and macrophages, and activates and degranulates basophils and mast cells. It was reported that Galectin-3 knock-out mice demonstrated reduced phagocytic properties in macrophages and Kupffer cells, indicating that this protein is involved in macrophage phagocytosis. Recently, Galectin-3 has been shown to be involved in cancer, inflammation, and fibrosis, heart disease, and stroke.?? It has also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, tissue repair, inflammation, fibrogenesis, and ventricular remodeling. In addition, Galectin-3 was found to contribute to the tumor cell evasion of the immune system. Galectin-3 is increasingly being used as a diagnostic marker for different cancers.? It can be screened for and used as a prognostic factor to predict the progression of the cancer. Overexpression of Galectin-3 is associated with neoplastic transformation, enhancement of tumor cell adhesion to the extracellular matirx, and the subsequent metastatic spreading of the cancer cells.
Size
500 μg
Concentration
n/a
Applications
BA
Other Names
Lectin, Galactoside-Binding, Soluble, 3 (LGALS3), L31, GAL3, MAC2, Carbohydrate-Binding Protein 35 (CBP35), Galactose Binding Protein (GALBP), GALIG, Galactose-Specific Lectin 3