human, mouse, rat, cross-reactivity: cynomolgus, rhesus, baboon
Isotype
IgG1, κ
Format
phycoerythrin (PE) conjugate
Size
25 tests
Concentration
n/a
Applications
Intracellular Staining for Flow Cytometry (ICFC)
Reviews / Ratings
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Description
PE anti-mouse/rat/human FOXP3. FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.
Immunogen
Full-length FOXP3 protein
Other Names
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2