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Description
Purified anti-human FOXP3 Delta 2 (exon 2 deleted). FOXP3 is a transcription factor which is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in scurfy mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 delta 2) lacking exon 2. This antibody reacts to human FOXP3 delta 2 (exon 2 deleted) form and weakly reacted to the full-length FOXP3.
Immunogen
Human FOXP3 delta2 (exon 2 deleted) peptide conjugated to KLH.
Other Names
Forkhead box protein P3, Scurfin, JM2, IPEX, Zinc finger protein JM2