The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36α, -β or -γ by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E. coli derived 17 kDa protein containing 154 amino acid residues.
Size
Various Sizes
Concentration
n/a
Applications
Cell Culture
Other Names
Interleukin-36 receptor antagonist protein;IL-36Ra ;Interleukin-1 HY1;IL-1HY1;Interleukin-1 delta;IL-1 delta;Interleukin-1 family member 5;IL-1F5;Interleukin-1 homolog 3;IL-1H3;Interleukin-1-like protein 1;IL-1L1;IL36RN;Fil1d, Il1f5, Il1h3, Il1hy1; FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1, delta