An inhibitor of 5-LO (IC50 = 70 nM for 5-LO product formation in A23187-challenged PMNLs); inhibits recombinant 5-LO in a glutathione peroxidase-dependent manner (IC50 = 300 nM); reduces levels of LTB4 and decreases mechanical hyperalgesia in a rat model of chronic inflammatory pain induced by Freund's adjuvant (3-10 mg/kg); reverses tactile allodynia and increases hind paw weight bearing in a rat medial meniscal transection model of osteoarthritic pain (0.6-6 mg/kg),