An ω-3 endocannabinoid epoxide and CB receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively); reduces the viability of 143B metastatic osteosarcoma cells at 25 μM; decreases the production of IL-6 and increases LPS-induced production of IL-10 in BV-2 microglia at 2.5-10 μM; decreases LPS-induced cytotoxicity in BV-2 microglia at 5-10 μM; decreases nitrite production at 7.5 μM, an effect that can be partially reversed by AM630 and GW 9662; induces vasodilation of isolated preconstricted bovine coronary arteries (ED50 = 1.9 μM); tube formation by HMVECs