E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Purity 99%. MW (observed): 207.25
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile. Bay 11-7082