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Description
The Neurofilament L/M/H Antibody Sampler Kit offers flexibility for sampling and detection of neurofilaments under normal and pathophysiological conditions. This selection of antibodies allows visualization of neuronal axons, dendrites, and cell bodies depending on the clone utilized. Clone SMI 31 reacts primarily with axons while clone SMI 32 visualizes neuronal cell bodies, axons, and dendrites. Clones SMI 35 and SMI 310 generally react with axons. Clone SMI 35 may be used to detect early neuronal cell pathology and intraneuronal neurofibrillary tangles in Alzheimer's disease (AD). Clone SMI 310 demonstrates strong reaction with extraneuronal (ghost) neurofibrillary tangles in AD. These antibodies provide an easy and rapid solution for multiplexing in ICC or IHC applications.