Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein (TNFSF13B) (Active)
Description
Purity > 95% as determined by SDS-PAGE. MW: 14 & 59kDa. Full Length: 31-152aa & 153-692aa. C-terminal Avi-tagged. Homo sapiens (Human). Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.