Cell-permeable. A derivative of Staurosporine (Cat. No. 1048) that inhibits a variety of serine/threonine and tyrosine kinases including protein kinase C (PKC) IC50 = 50 nM), cyclic AMP-dependent protein kinase (PKA) (IC50 = 2.4 μM), S6 kinase (IC50 = 5.0 μM), and EGFR (IC50 = 3.0 μM). PKC412 reverses the efflux function of the multidrug resistance (MDR)-1 gene product, P-glycoprotein (P-gp). MW: 570.64. Purity ≥99% by HPLC