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Description
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. This DOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human DOK1.
Immunogen
Human DOK1.
Other Names
docking protein 1; 62kDa (downstream of tyrosine kinase 1); DOK1; MGC117395; MGC138860; P62DOK; Downstream of tyrosine kinase 1; p62(dok); pp62; p62 (dok)