If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
DOK6 Polyclonal Antibody. DOK-6 (docking protein 6),is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules.Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that
Immunogen
n/a
Other Names
Docking protein 6; Downstream of tyrosine kinase 6; DOK5L; docking protein 5-like