Recombinant Rat CMRF35-like molecule 1 (Cd300lf), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 38.3kDa. Extracellular Domain: 19-181aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Rattus norvegicus (Rat). Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
CD300 antigen-like family member F; CD_antigen: CD300f