Recombinant Human Cell surface glycoprotein MUC18 (MCAM), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 70.7kDa. Partial: 50-646aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elents of the vascular syst, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during bryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.