A potent agonist of GPR35 (EC50 = 1.61 nM); inhibits histamine release in isolated rat peritoneal mast cells (IC50s = 0.1-50 μM); inhibits A23187-induced calcium influx in isolated rat mast cells; reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 μg/ml; dose-dependently reduces the immediate hypersensitivity response in rat conjunctiva in vivo; reduces mast cell degranulation in rat conjunctiva
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
Thilomide GPR-35 CHOK1 A-23187 antiIgE g protein-coupled receptor