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Description
TIFA Polyclonal Antibody. Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
Immunogen
n/a
Other Names
T2BP, T6BP, TIFAA, TRAF-interacting protein with FHA domain-containing protein A, TRAF-interacting protein with a forkhead-associated domain, TRAF2 binding protein, TRAF2-binding protein, TRAF6 binding protein, putative MAPK-activating protein PM14, putative NF-kappa-B-activating