If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description
UBE2V1 Polyclonal Antibody. The E2 enzyme, Ubc13, and the E2 enzyme variants, Uevs, form stable, high affinity complexes for the assembly of Lys63-linked ubiquitin chains. This complex has been shown to activate NF-kB signaling pathway by linking TRAF6 to IKKs. Blockade of this polyubiquitin chain synthesis, but not inhibition of the proteasome, prevents the activation of IKK by TRAF6. These results suggest a new regulatory function for ubiquitin, in which IKK is activated through the assembly of Lys63-linked polyubiquitin chains. The UEV proteins are also involved in the control of differentiation.