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Description
Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.Subcellular location: Membrane, Single-pass type II membrane protein.Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Also known as: Toll-like receptor 7.
Immunogen
A synthetic peptide from the extracellular domain of human TLR7 conjugated to an immunogenic carrier protein was used as the antigen.