TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2)
Clone
3B5
Host Species
Mouse
Reactive Species
human
Isotype
IgG1
Format
ascites
Size
0.1 mL
Concentration
n/a
Applications
Western Blotting (WB),Flow Cytometry (FACS),ELISA
Reviews / Ratings
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Description
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.Synonyms: CHTD2, FLJ21885, KIAA0733, MAP3K7IP2, TAB2
Immunogen
Purified recombinant fragment of human TAB2 expressed in E. Coli.