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Description
Function: Participates in the innate immune response to microbial agents. Detects the unmethylated cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.Subcellular location: Membrane, Single-pass type II membrane protein.Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. Also known as: Toll-like receptor 9.
Immunogen
A synthetic peptide from the cytoplasmic domain of human TLR9 conjugated to an immunogenic carrier protein was used as the antigen.