Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) protein (His tag)
Description
VEGFB is a growth factor for endothelial cells. VEGFB 167 AA binds heparin and neuropilin-1 while the binding to neuropilin-1 of VEGFB 186 AA is regulated by proteolysis. Overexpression of VEGFB in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Increased VEGFB expression is associated with hepatocellular carcinoma. VEGF-B has restricted angiogenic activity in the ischemic heart. VEGFB binds to VEGFR1, Flt1, but not to VEGFR2 and VEGFR3. VEGFB is homodimeric, heparin-binding glycoprotein involved in embryonic angiogenesis and vasculogenesis Synonyms: Vascular endothelial growth factor B, VEGF-B, VRF, VEGFL, VEGF-related factor, VEGFB