A potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins; sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro; produces radiosensitization and increases survival in vivo when administered intra-tumorally
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
925701-49-1 925701-48-0 894104-72-4 biochemical cancer inhibitor protein kinase DNA damage repair intracellular signaling KU60019 ataxia-telangiectasia mutated ATM inhibit