An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 μM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS