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Description
Recognizes an epitope within the N-terminal region of BACE2, a homologue of the beta-site APP cleaving enzyme (BACE). BACE2 has been reported to cleave the beta-amyloid precursor protein (APP) at the beta-site, producing amyloid-beta protein (ABeta). Accumulation of ABeta plaques in the cerebral cortex play an important role in the pathogenesis of Alzheimer's disease, particularly in individuals bearing the Flemish mutation. Species crossreactivity Mouse, rat
Immunogen
Synthetic peptide corresponding to amino acids 44-59 of human BACE2..
Other Names
BACE2, Asp1 (NT) (Beta-site APP Cleaving Enzyme, Aspartyl Protease 2, DRAP, Down Region Aspartic Protease, Memapsin)