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Description
Rabbit Anti-BACE1 Recombinant Antibody (BA0250). This product is a rabbit antibody that recognizes BACE1. The antibody BA0250 can be used for immunoassay techniques such as: IP, WB. This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. Vassar et al. (1999) found that transient overexpression of BACE did not affect APP expression, but decreased alpha-secretase cleavage and increased beta-secretase activity in cells expressing wildtype or Swedish mutant (104760.0008) APP. BACE overexpression induced cleavage only at the known beta-secretase positio