Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / Ratings
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Description
Reticulon-3, also known as RTN3 or NSPL2, is a protein that in humans is encoded by the RTN3 gene. It is mapped to 11q13, which is between markers D11S4535 and D11S4627. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1(BACE1), and the production of amyloid-beta. RTN3 colocalized with BACE1 in neurons of human brain gray matter, and overexpression of RTN3 in vitro inhibited BACE1 activity and decreased amyloid precursor protein processing.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human RTN3(1017-1032aa EKIQAKLPGIAKKKAE), identical to the related mouse and rat sequences.