Immunoprecipitation: 10 μg/mg lysate, Western Blot: 1:1,000-1:5,000
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Description
PGC-1beta Polyclonal Antibody. PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.