Purity ~95% (SDS-PAGE). TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells. Source: Recombinant protein corresponding to human LTA expressed in E. coli. Molecular Weight: ~19kD Biological Activity: The ED50 was measured in a cytotoxicity assay using mouse L929 cells in the presence of the metabolic inhibitor actinomycin, and was 0.1ng/mL. Endotoxin: <1EU/ug (LAL)
Size
20ug, 100ug
Concentration
n/a
Applications
n/a
Other Names
LTA, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 1, TNFSF1, Lymphotoxin-Alpha, LT-Alpha, Tumor Necrosis Factor Beta)