Recombinant Human Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1), partial
Description
Purity > 90% as determined by SDS-PAGE. MW: 40.1kDa. Partial of Isoform 3: 1-314aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.