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| Antigenic Specificity | IREM-2 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | PerCP conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The UP-H2 monoclonal antibody recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34 kDa Ig-like containing receptor is an activating receptor and through it's charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC's. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2.In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes. The Anti-CD300e is specific for monocytic lineage and myeloid dendritic cells. In normal peripheral blood it should be positive in at least 80% of monocytes and in bone marrow in 50%. The antibody can be used to classify myeloid leukaemias, especially those with monocytic component. |
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| Immunogen | IREM-2-HA-transfected cells. |
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| Other Names | IREM-2; CD300e; alfa-mar; mar; CMRF35-like molecule 2; CLM-2; CD300 antigen-like family member E; CMRF35-A5; Immune receptor expressed on myeloid cells 2; Polymeric immunoglobulin receptor 2; PIgR-2; Poly-Ig receptor 4; Poly-Ig receptor 5; Poly-Ig receptor 6; Poly-Ig receptor 7; Poly-Ig receptor 8; Poly-Ig receptor 9 |
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| Gene, Accession # | Gene ID: 342510, SwissProt: Q496F6 |
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| Catalog # | abx200517 |
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| Price | |
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| Order / More Info | IREM-2 Antibody from ABBEXA |
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| Product Specific References | n/a |
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