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Description
Rabbit IgG polyclonal antibody for Krueppel-like factor 5(KLF5) detection. Tested with WB in Human;Mouse;Rat. No cross reactivity with other proteins. KLF5(Krueppel-like factor 5) is a protein that in humans is encoded by the KLF5 gene. It is also known as BASIC TRANSCRIPTION ELEMENT-BINDING PROTEIN 2 or BTEB2. This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Suske et al.(2005)stated that the human KLF5 gene maps to chromosome 13q21.33, and the mouse Klf5 gene to chromosome 14E2.1. Sogawa et al.(1993)isolated a cDNA encoding BTEB2. The predicted 219-amino acid protein contains 3 consecutive zinc finger motifs near the C terminus. The zinc finger domains were 59% and 64% identical to those of Sp1(189906) and BTEB1, respectively. Both BTEB2 and Sp1 have a short basic region preceding the zinc finger motifs that may play an auxiliary role in DNA binding. The N-terminal region of BTEB2 is proline rich. Recombinant BTEB2 protein and Sp1 showed very similar DNA-binding specificity in vitro. When expressed in mammalian cells, BTEB2 activated the transcription of a reporter gene fused to a GC box-containing promoter. Sogawa et al.(1993) also identified the rat BTEB2 homolog. Northern blot analysis of rat tissues revealed that BTEB2 is expressed only in the testis and placenta.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human KLF5(109-126aa HKKYRRDSASVVDQFFTD), identical to the related rat and mouse sequences.
Other Names
Krueppel-like factor 5;Basic transcription element-binding protein 2;BTE-binding protein 2;Colon krueppel-like factor;GC-box-binding protein 2;Intestinal-enriched krueppel-like factor;Transcription factor BTEB2;KLF5;BTEB2, CKLF, IKLF;