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Description
Function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.Subcellular location: Cell membrane, Multi-pass membrane protein. Cell junction ?? synapse ?? postsynaptic cell membrane, Multi-pass membrane protein.Tissue specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes. Also known as: ACH10, Neuronal acetylcholine receptor subunit alpha-10, Nicotinic acetylcholine receptor subunit alpha-10, NACHR alpha-10, NACHRA10.
Immunogen
A synthetic peptide from c-terminal region of human CHRNA10 (Neuronal acetylcholine receptor subunit alpha-10) conjugated to an immunogenic carrier protein was used as the antigen.