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Description
Mouse Anti-Mouse CD45.1/Ly-5.1-UNLB. Specificity: Mouse CD 45.1 (Leukocyte Common Antigen)The CD45 antigen is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases.1, 2 This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation.1, 2 The functional state
1. Okumura, M. and M. L. Thomas. 1995. Current Opin. Immunol. 7:312-319. 2. Thomas. M. L. 1995. Seminars in Immunol. 7:279-288. 3. Mardiney, M and H. L. Malech. 1996. Blood 87:4049-4056. 4. Vallera, D. A., et al. 1994. Transplantation 57:249-256.