Recombinant Human Nucleoside diphosphate kinase A (NME1)
Description
Purity > 90% as determined by SDS-PAGE. MW: 44kDa. Full Length of Mature Protein: 2-152aa. N-terminal GST-tagged. Homo sapiens (Human). Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 roves bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Granzyme A-activated DNase; GAADMetastasis inhibition factor nm23NM23-H1Tumor metastatic process-associated protein