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Description
Rabbit IgG polyclonal antibody for Succinate dehydrogenase cytochrome b560 subunit, mitochondrial(SDHC) detection. Tested with WB, IHC-P in Human;Mouse;Rat. No cross reactivity with other proteins. SDHC(succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) also known as SDH3, SUCCINATE DEHYDROGENASE CYTOCHROME b. The SDHC gene contains 6 exons. Oostveen et al.(1995) found that in fact it was protein from the bovine SDH3 gene(encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation. The authors localized the human SDH3 gene to the short arm of chromosome one, within 1 to 2 Mb from the centromere. Additionally, the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes. Elbehti-Green et al.(1998) confirmed the assignment of the SDHC gene to 1q21 by FISH. Baysal et al.(2004) described a family with PGL3 in which an 8,372-bp deletion in the SDHC gene was transmitted both maternally and paternally, without evidence of genomic imprinting.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human SDHC(35-50aa KEEMERFWNKNIGSNR), different from the related mouse and rat sequences by three amino acids.
Other Names
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial;Integral membrane protein CII-3;QPs-1;QPs1;Succinate dehydrogenase complex subunit C;Succinate-ubiquinone oxidoreductase cytochrome B large subunit;CYBL;SDHC;CYB560, SDH3;